Khoddami, A., Ghazali, H.M., Yassoralipour, A., Ramakrishan, Y., dan Ganjloo, A. Penerjemah Bagian Mikrobiologi Fakultas Kedokteran Universitas Airlangga. Penerjemah: Bagian Mikrobiologi Kedokteran Universitas Airlangga. Jawetz, E, Melnick J.L., dan Adelberg, E.A. Buku Ajar Mikrobiologi : Panduan Mahasiswa Farmasi dan Kedokteran. Chemical Composition of The Fixed And Volatile Oils of Nigella sativa From Iran. Nickavar, B., Mojab, F., Javidnia, K., dan Amoli, M. Jawetz, E., Melnick, J.L., dan Adelberg, E.A. Indonesian Journal of Pharmaceutical Science And Technology. Aktivitas Antibakteri Ekstrak Dari Lima Tanaman Terhadap Bakteri Staphylococcus Epidermidis Dengan Metode Mikrodilusi M7 – A6CLSI. Suryana, S., Nuraeni, Y.Y.A., dan Rostinawati, T. Indian Journal of Dermatology, Venereology And Leprology. 24 Herbal Legendaris Untuk Kesehatan Anda. Penyakit Kulit, Perawatan, Pencegahan Dan Pengobatan.

The results of the antibacterial activity test showed the value of minimum inhibitory concentration (MIC) of Staphylococcus aureus bacteria in F1, F2 and F3 respectively 7,83 8,93 and 10,00 mm, Staphylococcus epidermidis bacteria 6,63 7,67 and 8,43 mm, Propionibacterium acne bacteria 6,43 7,47 and 7,83 mm.Ĭonclusion: The results of the study concluded that nanoemulsion gel of black cumin ethanol extract with a concentration of 7% is the best formula because it is stable during storage, has the greatest antibacterial activity against pathogenic bacteria in the skin.ġ. All formulas were stable during 12 weeks storage, viscosity 2850-3750 mPa.s, particle size around 45,85-419,78 nm, centrifugation results and cycling tests showed no sedimentation and phase separations, so it were said to be physically stable. Results: the extract yield was 18,37% w/w. Antibacterial activity test of nanoemulsion gel of black cumin ethanol extract was carried out by cup-plate technique using Staphylococcus aureus, Staphylococcus epidermidis dan Propionibacterium acne.

Evaluation of preparation quality includes organoleptic, viscosity, particle size, centrifugation and cycling test. The preparation is stored and evaluated for 12 weeks at room temperature. Black cumin ethanol extract is formulated into nanoemulsion gel using spontaneous emulsification with concentrations of 3%, 5% and 7%. Methods: Black cumin seeds macerated with 80% alcohol and concentrated with a rotary evaporator. This research was carried out by making ethanol extract of black cumin, formulating it into nanoemulsion gel and testing the antibacterial activity against pathogenic bacteria in the skin. Objective: Black cumin ( Nigella sativa L.) is an herbal plant that has the chemical content of essential oil and pharmacological effect as a broad-spectrum antibacterial namely thymoquinone (TQ).

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